منابع مشابه
Nuclear hormone receptors in C. elegans.
Nuclear receptors (NRs) are transcription factors typically regulated by lipophilic hormones, which coordinate metazoan metabolism, development and homeostasis. C. elegans has undergone a remarkable expansion of the family, harboring 284 of these receptors in its genome. Approximately 20 of them have been analyzed genetically, most of which correspond to conserved homologs in other metazoans. T...
متن کاملFunctional modularity of nuclear hormone receptors in a Caenorhabditis elegans metabolic gene regulatory network
Gene regulatory networks (GRNs) provide insights into the mechanisms of differential gene expression at a systems level. GRNs that relate to metazoan development have been studied extensively. However, little is still known about the design principles, organization and functionality of GRNs that control physiological processes such as metabolism, homeostasis and responses to environmental cues....
متن کاملNuclear Hormone Receptors in T Lymphocytes
Among the numerous steroid and orphan nuclear receptors encoded within mammalian genomes, several are involved in regulating immune system functions. We review here recent studies on the glucocorticoid receptor and the orphan receptors Nur77 and RORgamma. These molecules play key roles in the development and the effector functions of T lymphocytes.
متن کاملCell adhesion receptors in C. elegans.
C. elegans has numerous putative cell adhesion receptors, many of which have vertebrate homologues. The simple body plan of C. elegans, its optical transparency and genetic tractability make it well suited for the study of adhesion receptors and their associated complexes (reviewed by Cox and Hardin in this issue, pp. 1885-1897). We focus here on receptors that are likely to directly mediate ad...
متن کاملNuclear receptor signal transduction in C. elegans.
Nuclear receptors are transcription factors that often respond to small molecule metabolites and fat-soluble compounds to regulate gene expression. They broadly govern development, reproduction, metabolism, and homeostasis in diverse metazoan species and their dysregulation is associated with numerous diseases. Work in C. elegans has shed light on the seminal role of nuclear receptors in life h...
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ژورنال
عنوان ژورنال: WormBook
سال: 2006
ISSN: 1551-8507
DOI: 10.1895/wormbook.1.64.1